• Academy of Science Fiction, Fantasy & Horror Films (Saturn Award)
*Nominated: Best Actress, The Forgotten (2005)

• BAFTA Award
* Nominated: Best Actress, The End of the Affair (2000)
* Nominated: Best Supporting Actress, The Hours (2003)

• Berlin International Film Festival
* Won: Silver Bear for Best Actress, The Hours (2002)

• Broadcast Film Critics Association
*Nominated: Best Actress, Far From Heaven (2002)
*Won: Best Actress, Far From Heaven (2003)

• Blockbuster Entertainment Awards
*Nominated: Favorite Actress, The Lost World: Jurassic Park (1997)
*Nominated: Favorite Supporting Actress, Magnolia (1999)

• Boston Society of Film Critics Awards
* Won: Best Actress, Vanya on 42nd Street (1994)

• Chicago Film Critics Association
*Nominated: Best Actress, The End Of The Affair (1999)
*Nominated:Best Supporting Actress, An Ideal Husband (1999)
*Won: Best Actress, Far From Heaven (2002)
*Nominated: Best Supporting Actress, The Hours (2002)

• Chlotrudis Awards
* Nominated: Best Actress, Vanya on 42nd Street (1994)
* Nominated: Best Actress, Safe (1995)
* Nominated: Best Supporting Actress, Boogie Nights (1997)
* Nominated: Best Actress, The End of the Affair (1999)
* Won: Best Actress, Far from Heaven (2002)

• Dallas-Fort Worth Film Critics Association Awards
*Won: Best Supporting Actress, Cookie's Fortune (1999)
*Won: Best Actress, Far from Heaven (2002)

• Daytime Emmy Award
* Won: Outstanding Ingenue in a Drama Series, As the World Turns (1988)

• Empire Awards
*Nominated: Best Actress, Far from Heaven (2002)

• Florida Film Critics Circle Awards
*Won: Best Supporting Actress, Boogie Nights (1997)
*Won: Best Ensemble Cast, Boogie Nights (1997)
*Won: Best Ensemble Cast, Magnolia (1999)
*Won: Best Actress, Far from Heaven (2002)

• GLAAD Media Awards
*Won: Excellence in Media Award (2004)

• Golden Globe Award
* Won: Best Ensemble Cast, Short Cuts (1994)
* Nominated: Best Supporting Actress - Motion Picture, Boogie Nights (1998)
* Nominated: Best Actress - Motion Picture Drama, The End of the Affair (2000)
* Nominated: Best Actress - Motion Picture Musical/Comedy, An Ideal Husband (2000)
* Nominated: Best Actress - Motion Picture Drama, Far from Heaven (2003)

• Gotham Awards
*Won: Actor Award (2002)

• Independent Spirit Award
*Nominated: Best Supporting Actress, Short Cuts (1993)
*Nominated: Best Actress, Safe (1995)
*Won: Best Actress, Far From Heaven (2002)

• Kansas City Film Critics Circle Awards
*Won: Best Actress, Far from Heaven (2002)

• L.A. Film Critics Association
*Won: Best Supporting Actress, Boogie Nights (1997)
*Won: Best Actress, The Hours (2002)
*Won: Best Actress, Far From Heaven (2002)

• Las Vegas Film Critics Society Awards
*Nominated Best Supporting Actress, The Hours (2002)

• London Critics Circle Film Awards
*Won: Actress of the Year, The End of the Affair (1999)
*Won: Actress of the Year, Far from Heaven (2002)

• MTV Movie Awards
*Nominated: Best Kiss, Hannibal (2001)

• National Board of Review
* Won: Best Supporting Actress, Map of the World (1999)
* Won: Best Supporting Actress, Magnolia (1999)
* Won: Best Supporting Actress, An Ideal Husband (1999)
* Won: Best Supporting Actress, Cookie's Fortune (1999)
* Won: Best Actress, Far From Heaven (2002)

• National Society of Film Critics
*Won: Best Supporting Actress, Boogie Nights (1997)
*Won: Best Supporting Actress (Runner-up), Map of the World (1999)
*Won: Best Supporting Actress (Runner-up), Magnolia (1999)
*Won: Best Supporting Actress (Runner-up), An Ideal Husband (1999)
*Won: Best Supporting Actress (Runner-up), Cookie's Fortune (1999)

• Online Film Critics Society Awards
* Nominated: Best Supporting Actress, The Myth of Fingerprints (1997)
* Nominated: Best Supporting Actress, Magnolia (1999)
* Won: Best Actress, Far from Heaven (2002)

• People's Choice Awards
*Nominated: Favorite Female Movie Star (2005)

• Phoenix Film Critics Society Awards
*won: Best Actress in a Leading Role, Far from Heaven (2002)
*Nominated: Best Acting Ensemble, The Hours (2002)

• San Diego Film Critics Society Awards
*won: Best Actress, Far from Heaven (2002)

• Sant Jordi Awards
*won: Best Foreign Actress (Mejor Actriz Extranjera), The Hours (2002)

• Satellite Awards
*won: Best Performance by an Actress in a Supporting Role in a Motion Picture, Boogie Nights (1997)
*Nominated: Best Performance by an Actress in a Supporting Role in a Motion Picture, The Big Lebowski (1998)
*Nominated: Best Performance by an Actress in a Motion Picture, An Ideal Husband (1999)
*Nominated: Best Performance by an Actress in a Supporting Role, The Hours (2002)
*Nominated: Best Performance by an Actress in a Motion Picture, Far from Heaven (2002)
*Nominated: Outstanding Actress in a Motion Picture, The Prize Winner of Defiance, Ohio (2005)

• Screen Actors Guild
*Nominated: Best Supporting Actress, Boogie Nights (1997)
*Nominated: Best Female Actor in a Supporting Role, Magnolia (1999)
*Nominated: Best Female Actor in a Leading Role, The End of the Affair (1999)
*Nominated: Best Supporting Actress, The Hours (2002)
*Nominated: Best Actress, Far From Heaven (2002)

• Seattle Film Critics Awards
*won: Best Actress, Far from Heaven (2002)

• Silver Bear Award
* Won: Best Actress for The Hours (2002)

• Soap Opera Digest Awards
*Nominated: Outstanding Actress in a Supporting Role: Daytime, "As the World Turns" (1956)

• Southeastern Film Critics Association Awards
*won: Best Actress, Far from Heaven (2002)

• Sundance Film Festival
*Won: Tribute to Independent Vision Award (2001)

• Teen Choice Awards
*Nominated: Choice Movie Scary Scene, The Forgotten (2004)

• Toronto Film Critics Association
*Won: Best Actress, Far From Heaven (2002)

• TV Land Awards
*Nominated: Little Screen/Big Screen Star (Women)

• Vancouver Film Critics Circle
*Won: Best Actress, Far from Heaven (2002)

• Venice International Film Festival
* Best Cast for Short Cuts (1994)
* Won: Best Actress for Far from Heaven (2002)

• Washington DC Area Film Critics Association Awards
*won: Best Actress, Far from Heaven (2002)